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이달의 논문 2025년 5월
등록일 : 2025.08.12
 doi: 10.1055/a-2530-5875. eCollection 2025 May.

Lipedema: Clinical Features, Diagnosis, and Management

Affiliations 

Abstract

Lipedema is an adipose tissue disorder that principally affects women and is frequently misidentified as obesity or lymphedema. There have been relatively few studies that have precisely defined the pathogenesis, epidemiology, and treatment approaches for lipedema. However, successfully recognizing lipedema as a distinct condition is important for proper management. This review aimed to examine the existing literature on the epidemiology, pathogenesis, clinical presentation, differential diagnosis, and treatments for lipedema. The current research indicates that lipedema appears to be a clinical entity related to genetic factors and fat distribution, although distinct from lymphedema and obesity. Some available treatments include complex decongestive physiotherapy, liposuction, and laser-assisted lipolysis. The management of lipedema is complex and differs from that of lymphedema. Further high-quality randomized controlled trials are urgently needed to continue advancing our understanding of this often neglected disease and exploring optimal medical and surgical treatment regimens tailored specifically for lipedema patients. In summary, despite frequent misdiagnosis, enhanced recognition, and research into customized therapeutic strategies for this poorly characterized but likely underdiagnosed disorder represent promising steps forward. Level of evidence N/A.

Keywords: lipedema; liposuction; lymphedema.

 

 

 

 

2025 May 22;13(5):e6822.

 doi: 10.1097/GOX.0000000000006822. eCollection 2025 May.

 

Epithelial Turn-in Flap for Nasal Lining Reconstruction

 

Jessica S. Wang, MD*; Rocio Perez, MD†; Lee J. Yuan, MD†; Jong-Woo Choi, MD, PhD, MMM†

 

 

INTRODUCTION Full-thickness nasal defects pose a unique challenge for the reconstructive surgeon, as all layers of the nose must be addressed: the skin, the support, and the lining. Early attempts at nasal reconstruction focused on external resurfacing, which led to results marred by contracture.1,2 Thanks to the efforts of Menick and Millard, the importance of nasal lining reconstruction is now widely recognized.1,2 Addressing the internal lining helps to prevent tissue contracture, cartilage necrosis and aesthetic deformity.3 Current options for nasal lining reconstruction range from skin grafts to free tissue transfer.1,4,5 Skin grafts can be placed intranasally when the wound bed is small (less than 1.5 cm) and vascularized.1,3,5 Composite grafts may be used to provide simultaneous lining and support. However, grafts will inevitably contract, so if the wound is near the alar rim, this method will lead to visible deformity.3,5 A pedicled flap, typically a forehead flap, can be folded onto itself distally to line the nostril rim, but poor visualization during inset and tissue stiffness makes precise positioning difficult.5 Folding of the most distal aspect of the flap may also compromise vascularity.3,4 Furthermore, the resultant rim often appears bulky and requires further revision.3 Intranasal mucosal flaps provide highly vascular, thin, physiologic tissue for lining reconstruction. However, they are technically challenging to raise, cause significant intranasal morbidity (ie, septal perforation, airway narrowing), may be unavailable due to trauma, and are limited in size.3–5 Free tissue transfer, such as radial forearm free f lap, is another option, but the distant donor-site scar is not appealing to many patients. Additionally, poor color and texture match to facial skin requires the external surface to be replaced with a forehead flap.

 

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